![]() ![]() Instead, the polymer nanoparticles were degraded and only the insulin part entered the beta cells triggering a cascade of signalling events leading to secretion of insulin from beta cells.Īt low dose, nano-insulin appeared in various cell tissues. Nano-insulin did not enter the beta cells in pancreas that secrete insulin. The study revealed that nano-insulin had greater efficacy in modulating diabetes-related physiological anomalies such as higher blood glucose, cholesterol and triglyceride levels than non-coated insulin. For comparison they used similar untreated mice and mice treated with normal non-coated insulin. They then injected arsenic-exposed diabetic mice with nano-insulin. In the hope of finding a nanoparticles-based insulin delivery technique, Khuda-Bukhsh and colleagues encapsulated dried insulin particles with poly (lactic-co-glycolic) acid (PLGA), a type of non-toxic and biodegradable polymer nanoparticles. However, no previous studies have investigated the insulin-ferrying potential of such nanoparticles. In recent years, nanoparticles have emerged as excellent drug carriers that could deliver insulin in a protective coat. In addition, constant arsenic exposure through drinking water destroys the insulin molecule before it can yield any therapeutic benefits. įor poverty-stricken arsenic victims, insulin treatment is expensive. This raises the possibility of using nano-insulin as anti-diabetic therapy in arsenic victims, he told Nature India. "Nano-insulin successfully combats arsenic-induced diabetes at a dose ten times lower than that of normal insulin in mice," said lead researcher Anisur Rahman Khuda-Bukhsh from the Department of Zoology at University of Kalyani. ![]() ![]() They call the coated product nano-insulin. They have successfully used the nano-therapy to alleviate symptoms of arsenic-induced diabetes in mice. They have overcome this long-standing problem by wrapping insulin in a coat of polymer nanoparticles to protect insulin from the effect of arsenic 1. Researchers from University of Kalyani in West Bengal now bring new hope. Insulin treatment has had limited success among such people since arsenic disrupts the therapeutic process. So what happens to diabetics living in areas with arsenic contamination of ground water? They suffer a double whammy: one, of arsenic poisoning and two, of unsuccessful diabetes treatment. ![]()
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